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Semaglutide increases the levels of GLP-1 in the body

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Interestingly, GLP-1RAs are known to reduce appetite and food intake partly via appetite-inhibitory neurotransmission signaling within the arcuate nucleus [16, 17], possibly resulting in subsequent improvements in insulin resistance and serum lipid profiles (e.g., reduction in triglyceride levels)

These signals collectively stabilize GPX4 activity and limit lipid-peroxide accumulation, thereby shielding tumor cells from ferroptotic death

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